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programmed cell death 6-interacting protein; PDCD6-interacting protein; ALG-2 interacting protein 1; Hp95 (PDCD6IP, AIP1, KIAA1375)
Class E VPS protein
Function:
1) concentration & sorting of cargo proteins in the multivesicular body pathway as (component of ESCRT1)
2) apoptosis
3) cell proliferation
4) interacts with ESCRT3 components CHMP4A, CHMP4B & CHMP4C
5) interacts with TSG101
Pathology:
1) interacts with viral proteins HIV-1 p6 & EIAV p9
2) the HIV-1 virus hijacks PDCD6IP for viral exocytosis & budding, via its interaction with HIV-1 p6 protein
Related
programmed cell death protein 6; apoptosis-linked gene 2 protein; Ca+2-binding protein ALG-2 (PDCD6, ALG2)
General
other protein
Properties
SIZE: MW = 96 kD
entity length = 868 aa
MOTIF: BRO1 {1-167}
proline-rich region
SITE: 717-860
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 608074
UniProt Q8WUM4
Pfam PF03097
Entrez Gene 10015
References
UniProt :accession Q8WUM4
Component-of
endosomal sorting complex required for transport-1 (ESCRT1)