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cyclin-dependent kinase-17 (CDK17); serine/threonine protein kinase PCTAIRE-2; PCTAIRE-motif protein kinase 2 (PCTK2)
Function:
- may play a role in terminally differentiated neurons
- Ser/Thr-phosphorylating activity for histone H1
- found in a complex containing CABLES1, PCTK1 & TDRD7
- interacts with TDRD7 (putative)
Structure:
- belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
- contains 1 protein kinase domain
General
cyclin-dependent kinase (CDK)
serine/threonine kinase PCTAIRE
Properties
SIZE: entity length = 523 aa
MW = 60 kD
STATE: active state
MOTIF: Ser phosphorylation site {S9}
Ser phosphorylation site {S105}
Ser phosphorylation site {S122}
Ser phosphorylation site {S137}
Ser phosphorylation site {S146}
Ser phosphorylation site {S165}
Ser phosphorylation site {S180}
kinase domain
SITE: 192-473
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 198-206
Tyr phosphorylation site {Y203}
Thr phosphorylation site {T205}
ATP-binding site
NAME: ATP-binding site
SITE: 221-221
aspartate residue {D313}
Ser phosphorylation site {S520}
Database Correlations
OMIM 603440
UniProt Q00537
Pfam PF00069
Entrez Gene 5128
Kegg hsa:5128
ENZYME 2.7.11.22
References
- UniProt :accession Q00537
Component-of
CABLES1/PCTK1/PCTK2/TDRD7 complex