Search
pericentrin; pericentrin-B; kendrin (PCNT, KIAA0402, PCNT2)
Function:
- integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis & meiosis
- plays a role, together with DISC1, in the microtubule network formation
- integral component of the pericentriolar material (PCM)
- interacts with DISC1 & PCM1. binds calmodulin
Structure:
- composed of a coiled-coil central region flanked by non-helical N-terminal & C-terminal
Compartment:
- cytoplasm, cytoskeleton, centrosome
- centrosomal at all stages of the cell cycle
- remains associated with centrosomes following microtubule depolymerization
- colocalized with DISC1 at the centrosome
Expression:
- expressed in all tissues tested, including placenta, liver, kidney & thymus
Pathology:
- defects in PCNT are the cause of microcephalic osteodysplastic primordial dwarfism type 2
General
phosphoprotein
Properties
SIZE: entity length = 3336 aa
MW = 378 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S54}
glutamate-rich region {214-795}
MOTIF: glutamate residue (SEVERAL)
coiled coil {258-553}
Ser phosphorylation site {S366}
coiled coil {675-835}
coiled coil {1010-1146}
coiled coil {1299-1949}
MOTIF: Ser phosphorylation site {S1688}
Ser phosphorylation site {S1703}
Ser phosphorylation site {S1712}
Ser phosphorylation site {S2044}
coiled coil {2064-2082}
Ser phosphorylation site {S2177}
Ser phosphorylation site {S2327}
coiled coil {2536-3086}
MOTIF: Ser phosphorylation site {S2900}
Ser phosphorylation site {S2963}
binding site
SITE: 3195-3208
FOR-BINDING-OF: calmodulin
Ser phosphorylation site {S3274}
Database Correlations
OMIM correlations
MORBIDMAP 605925
UniProt O95613
Pfam PF10495
Entrez Gene 5116
Kegg hsa:5116
References
UniProt :accession O95613