polycomb group RING finger protein 6 (RING finger protein 134, Mel18 & Bmi1-like RING finger, PCGF6, MBLR, RNF134)

Function: 1) transcriptional repressor 2) interacts with PCGF4, RING1, RNF2 3) phosphorylated during mitosis Structure: - contains 1 RING-type zinc finger Compartment: nucleus Alternative splicing: named isoforms=3 Expression: ubiquitous Polymorphism: - poly-Pro stretch (P24-P28) may be polymorphic, varies from 5-7 Pro residues

General

phosphoprotein ring finger protein transcriptional silencer (transcriptional repressor)

Properties

SIZE: MW = 39 kD entity length = 350 aa COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 22-66 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S30} glutamate-rich region {63-120} MOTIF: glutamate residue (SEVERAL) coiled coil {72-110} RING-finger {134-173} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif

Database Correlations

OMIM 607816 UniProt Q9BYE7

References

UniProt :accession Q9BYE7