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poly(rC)-binding protein 2 (alpha-CP2, hnRNP-E2, PCBP2)
Function:
1) major cellular poly(rC)-binding protein
2) also binds poly(rU)
3) phosphorylation diminishes poly(rC)-binding activity
Structure:
- contains 3 KH domains
Compartment:
- nucleus, cytoplasm
- loosely bound in nucleus
- may shuttle between nucleus & cytoplasm
Expression: ubiquitously expressed
General
phosphoprotein
RNA-binding protein
Properties
SIZE: MW = 39 kD
entity length = 365 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: KH domain
SITE: 13-75
FOR-BINDING-OF: ribonucleic acid
KH domain
SITE: 97-162
FOR-BINDING-OF: ribonucleic acid
Tyr phosphorylation site {Y236}
KH domain
SITE: 287-351
FOR-BINDING-OF: ribonucleic acid
Database Correlations
OMIM 601210
UniProt Q15366
Pfam PF00013
References
UniProt :accession Q15366