PCAF complex; coactivator for p53/TP53-dependent transcriptional activation; PCAF histone acetylase complex

Function: 1) acetylates histones within a nucleosome 2) human analog of the yeast SAGA complex Structure: - subunits: - TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65beta, TAF6L/PAF65alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31, TRRAP, SUPT3H

General

histone acetyltransferase molecular complex

Properties

COMPARTMENT: cell nucleus MOTIF: active site SUBUNITS: TAF6-like RNA polymerase II p300 MOTIF: Ser phosphorylation site {S85} TAF5-like RNA polymerase II p300 MOTIF: WD repeat {266-305} WD repeat {340-379} WD repeat {382-421} WD repeat {424-463} WD repeat {466-505} WD repeat {508-547} histone acetyltransferase PCAF MOTIF: Ser phosphorylation site {S40} N-acetyltransferase {503-651} Tyr phosphorylation site {Y729} bromodomain {740-810} transcription initiation factor TFIID subunit 12 MOTIF: Thr phosphorylation site {T43} Ser phosphorylation site {S51} Thr phosphorylation site {T59} transcription initiation factor TFIID subunit 10 MOTIF: [KR]-[STA]-K {187-189} transcription initiation factor TFIID subunit 9 MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S85} DNA-binding motif SITE: 120-137 Ser phosphorylation site {S149} Ser phosphorylation site {S155} Ser phosphorylation site {S158} Thr phosphorylation site {T159} Thr phosphorylation site {T161} Thr phosphorylation site {T178} Ser phosphorylation site {S181} transcription initiation factor TFIID subunit 6 MOTIF: Ser phosphorylation site {S626} Ser phosphorylation site {S634} Ser phosphorylation site {S636} Ser phosphorylation site {S653} Thr phosphorylation site {T660} Ser phosphorylation site {S670} Ser phosphorylation site {S672} transcription initiation factor TFIID subunit 5 MOTIF: glycine-rich region {46-49} LisH {92-124} lysine-rich region {399-407} MOTIF: lysine residue (SEVERAL) WD repeat {468-507} WD repeat {541-580} WD repeat {583-624} WD repeat {625-666} WD repeat {667-706} WD repeat {709-748} transformation/transcription domain-associated protein MOTIF: proline-rich region SITE: 485-526 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S1628} TP53 interaction {2010-2388} MOTIF: nuclear translocation signal {2047-2062} Ser phosphorylation site {S2051} Ser phosphorylation site {S2077} Thr phosphorylation site {T2333} Thr phosphorylation site {T2601} FAT domain NAME: FAT domain SITE: 2704-3275 MOTIF: Tyr phosphorylation site binding site FOR-BINDING-OF: Paxillin PI3K/PI4K {3528-3826} FATC {3827-3859} transcriptional adapter 2-like COMPARTMENT: cell nucleus MOTIF: cysteine-rich region {17-45} SANT {70-122} SWIRM {356-443} MOTIF: DNA-binding motif SITE: 426-435 transcription initiation protein SPT3 homolog COMPARTMENT: cell nucleus

References

UniProt :accession O75529

Components

histone acetyltransferase PCAF; histone acetylase PCAF; P300/CBP-associated factor; P/CAF (PCAF, KAT2B) TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kD subunit 5L; PCAF-associated factor 65-beta; PAF65-beta (TAF5L, PAF65B) TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kD subunit 6L; PCAF-associated factor 65-alpha; PAF65-alpha (TAF6L PAF65A) transcription initiation factor TFIID subunit 10; STAF28; transcription initiation factor TFIID 30 kD subunit; TAF(II)30; TAFII-30; TAFII30 (TAF10, TAF2A, TAF2H, TAFII30) transcription initiation factor TFIID subunit 12; transcription initiation factor TFIID 20/15 kD subunits; TAFII-20/TAFII-15; TAFII20/TAFII15 (TAF12, TAF15, TAF2J, TAFII20) transcription initiation factor TFIID subunit 5; p100TFIID; transcription initiation factor TFIID 100 kD subunit; TAF(II)100; TAFII-100; TAFII100 (TAF5, TAF2D) transcription initiation factor TFIID subunit 6; p70TFIID; RNA polymerase II TBP-associated factor subunit E; transcription initiation factor TFIID 70 kD subunit; TAF(II)70; TAFII-70; TAFII70; transcription initiation factor TFIID 80 kD subunit; TAF(II)80; TAFII-80; TAFII80 (TAF6, TAF2E, TAFII70) transcription initiation factor TFIID subunit 9; RNA polymerase II TBP-associated factor subunit G; STAF31/32; transcription initiation factor TFIID 31 kD subunit; TAFII-31; TAFII31; transcription initiation factor TFIID 32 kD subunit; TAFII-32; TAFII32 (TAF9, TAF2G, TAFII31) transcription initiation protein SPT3 homolog (SPT3-like protein, SUPT3H, SPT3) transcriptional adapter 2-like; ADA2-like protein (TADA2L, TADA2A) transformation/transcription domain-associated protein; 350/400 kD PCAF-associated factor; PAF350/400; STAF40; tra1 homolog (TRRAP, PAF400)