pre-B-cell leukemia transcription factor-interacting protein 1 (hematopoietic PBX-interacting protein, PBXIP1, HPIP)

Function: - regulator of pre-B-cell leukemia transcription factors (BPXs) function - inhibits the binding of PBX1-HOX complex to DNA & blocks the transcriptional activity of E2A-PBX1 - tethers estrogen receptor-alpha (ESR1) to microtubules & allows them to influence estrogen receptors-alpha signaling - interacts with ESR1, PBX1, PBX2 & PBX3 Structure: - C-terminal domain (AA 443-731) contains a nuclear export signal - association with cytoskeleton through N-terminal leucine rich-domain (AA 190-218) Compartment: - cytoplasm, cytoskeleton, nucleus - shuttles between the nucleus & the cytosol - mainly localized in the cytoplasm, associated with microtubules - detected in small amounts in the nucleus Alternative splicing: named isoforms=3 Expression: expressed in early hematopietic precursors

Properties

SIZE: entity length = 731 aa MW = 81 kD MOTIF: Ser phosphorylation site {S45} Ser phosphorylation site {S146} Ser phosphorylation site {S147} Ser phosphorylation site {S148} Thr phosphorylation site {T152} arginine-rich region {160-165} MOTIF: arginine residue (SEVERAL) coiled coil {270-348} coiled coil {377-417} nuclear translocation signal {485-505} nuclear translocation signal {695-720} histidine-rich region {721-729} MOTIF: histidine residue (SEVERAL)

References

UniProt :accession Q96AQ6