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protein polybromo-1; hPB1; polybromo-1D; BRG1-associated factor 180 (PBRM1, BAF180, PB1)
Function:
1) role in transcriptional activation & repression by chromatin
2) component of the SWI/SNF chromatin-remodeling complex
Structure:
- contains 2 BAH domains contains 6 bromo domains contains 1 HMG box DNA-binding domain
Compartment: nucleus
Alternative splicing: named isoforms=6
Expression: widely expressed
General
nuclear protein
phosphoprotein
Properties
SIZE: MW = 193 kD
entity length = 1689 aa
COMPARTMENT: cell nucleus
MOTIF: Tyr phosphorylation site {Y54}
bromodomain {64-134}
bromodomain {200-270}
bromodomain {400-470}
bromodomain {538-608}
Ser phosphorylation site {S636}
Bromo 5 {676-746}
Bromo 6 {792-862}
BAH 1 {956-1074}
BAH 2 {1156-1272}
HMG box
SITE: 1379-1447
Ser phosphorylation site {S1453}
proline-rich region
SITE: 1468-1599
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 606083
UniProt Q86U86
PFAM correlations
References
UniProt :accession Q86U86