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paired box protein PAX4 (PAX4)
Function:
- role in the differentiation & development of pancreatic islet beta cells
- transcriptional repressor that binds to a common element in the glucagon, insulin & somatostatin promoters
- competes with PAX6 for this same promoter binding site
- Pax4v isoform appears to be a dominant negative form antagonizing PAX4 transcriptional activity
Structure:
- belongs to the paired homeobox family
- contains 1 homeobox DNA-binding domain
- contains 1 paired domain
Compartment: nucleus
Alternative splicing: named isoforms=3
General
paired box protein (PAX)
Properties
SIZE: MW = 38 kD
entity length = 350 aa
COMPARTMENT: cell nucleus
MOTIF: paired box
SITE: 5-129
homeodomain
SITE: 170-229
silencer element
SITE: 278-350
Database Correlations
OMIM 167413
MORBIDMAP 167413
UniProt O43316
PFAM correlations
Entrez Gene 5078
Kegg hsa:5078
References
- UniProt :accession O43316
- Entrez Gene :accession 5078