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paternal age
Notes:
- spontaneous genetic mutations occur during spermatogenesis & are passed on to children
- most spontaneous genetic mutations come from the father
- the rate of spontaneous genetic mutation increases with the father's age at conception
- paternal age is a risk factor for autism & schizophrenia
- advancing paternal age is associated with increased risk of psychiatric & academic morbidity [2]
- paternal age >= 45 years associated with premature birth, lower Apgar scores, admission to neonatal ICU [3]
- also associated with increased risk of gestational diabetes in mothers (may be due to placental health)
References
- Physician's First Watch, Aug 27 2012
Massachusetts Medical Society
http://www.jwatch.org
- Kong A et al
Rate of de novo mutations and the importance of father's age
to disease risk
Nature 488, 471-475 (23 August 2012)
PMID: 22914163
http://www.nature.com/nature/journal/v488/n7412/full/nature11396.html
- Kondrashov A
Genetics: The rate of human mutation
Nature 488, 467-468 (23 August 2012)
PMID: 22914161
http://www.nature.com/nature/journal/v488/n7412/full/488467a.html
- D'Onofrio BM et al.
Paternal age at childbearing and offspring psychiatric and
academic morbidity.
JAMA Psychiatry 2014 Feb 26
PMID: 24577047
http://archpsyc.jamanetwork.com/article.aspx?articleid=1833092
- Khandwala YS, Baker VL, Shaw GM et al
Association of paternal age with perinatal outcomes between 2007
and 2016 in the United States: population based cohort study.
BMJ 2018;363:k4372
PMID: 30381468 Free full text
https://www.bmj.com/content/363/bmj.k4372
- Brown HK
Paternal factors in preconception care: the case of paternal age.
BMJ 2018;363:k4466
PMID: 30381463
https://www.bmj.com/content/363/bmj.k4466