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alpha-parvin (calponin-like integrin-linked kinase binding protein, CH-ILKBP, PARVA)
Function:
1) role in regulation of cell adhesion & cytoskeleton organization (putative)
2) interacts with integrin-linked protein kinase & actin
Structure:
- belongs to the parvin family
- contains 2 CH domains (calponin-homology domains)
Compartment:
- cell junction, focal adhesion, cytoplasmic side
- constituent of focal adhesions
Alternative splicing: named isoforms=2
Expression:
- widely expressed, with highest levels in heart, skeletal muscle, kidney & liver
General
parvin (PARV)
Properties
SIZE: MW = 42 kD
entity length = 372 aa
COMPARTMENT: cytoplasm
MOTIF: calponin homology domain
NAME: calponin homology domain
SITE: 95-201
calponin homology domain
NAME: calponin homology domain
SITE: 262-369
Database Correlations
UniProt Q9NVD7
Pfam PF00307
References
UniProt :accession Q9NVD7