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paraneoplastic subacute sensory neuronopathy

Etiology: 1) mediator: unknown 2) associated neoplasms: lung, especially small cell Pathology: 1) inflammation & dorsal root degeneration in dorsal root ganglia 2) secondary axonal loss Clinical manifestations: 1) evolution over weeks to months 2) may precede other manifestations of malignancy 4) severe sensory loss with areflexia & ataxia 5) paresthesias, pain 6) ataxia 7) may be purely painful or purely ataxic Laboratory: - anti-Hu antibodies (50%) - nerve biopsy Special laboratory: - nerve conduction studies

General

paraneoplastic neurologic syndrome

References

  1. Oki Y et al, Ataxic vs painful form of paraneoplastic neuropathy. Neurology 2007, 69:564 PMID: 17679675
  2. Camdessanche JP, Jousserand G, Ferraud K et al The pattern and diagnostic criteria of sensory neuronopathy: a case-control study. Brain. 2009 Jul;132(Pt 7):1723-33 PMID: 19506068