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pannexin-1 (PANX1, MRS1, UNQ2529/PRO6028)
Function:
- structural component of the gap junctions
- forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes
Structure: belongs to the pannexin family
Compartment:
- cell membrane; multi-pass membrane protein (putative)
- cell junction, gap junction
Alternative splicing: named isoforms=2
General
pannexin
Properties
SIZE: entity length = 426 aa
MW = 48 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-40}
transmembrane domain {41-61}
exoplasmic loop {62-106}
transmembrane domain {107-127}
cytoplasmic loop {128-217}
transmembrane domain {218-238}
exoplasmic loop {239-266}
MOTIF: N-glycosylation site {N255}
transmembrane domain {267-287}
cytoplasmic domain {288-426}
Database Correlations
OMIM 608420
UniProt Q96RD7
Pfam PF00876
Entrez Gene 24145
Kegg hsa:24145
References
- UniProt :accession Q96RD7
- Wikipedia; Note: pannexin entry
http://en.wikipedia.org/wiki/pannexin