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pancreatic polypeptide; pancreatic hormone; Obinepitide (PPY, PNP, PP)
Function:
- all ingested nutrients stimulate pancreatic polypeptide release
- protein is the most potent food simulus
- release is mediated by vagal stimulation
Structure: belongs to the NPY family
Compartment: secreted
Expression:
- synthesized in pancreatic islets of Langerhans
Pathology:
- may be cause of watery diarrhea in patients with islet cell tumors
Pharmacology:
- Obinepitide is under clinical trial by 7TM pharma to be used for treatment of obesity
- Obinepitide is derived from pancreatic hormone
Related
pancreatic polypeptide in plasma
General
neuropeptide
pancreatic hormone
Properties
SIZE: MW = 4.23 kD
MW = 10 kD
entity length = 95 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-29}
SECRETED-BY: F cell
WITHIN: islets of Langerhans
Database Correlations
OMIM 167780
UniProt P01298
Pfam PF00159
Entrez Gene 5539
Kegg hsa:5539
References
- Clinical Chemistry, Theory, Analysis & Correlation,
2nd ed., Kaplan & Pesce (eds), CV Mosby, St.Louis,
1989 pg 392
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- UniProt :accession P01298