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pancreatic islet cell transplantation

Indications: - diabetes mellitus type-1 Procedure: 1) infusion of cadaveric donor islets into the portal vein* a) immunosuppression - sirolimus - tacrolimus -daclizumab b) more than one transplantation procedure is generally needed 2) stem cell transplantation (investigational) - transplant of chemically-induced pluripotent stem-cell-derived islets under the abdominal anterior rectus sheath in a woman with type-1 diabetes [3] - reprogrammed autologous stem cells transformed into insulin-producing islet cells transplanted into the liver of a man with type-2 diabetes [4] * Historically, successful in < 10% of patients. Newer protocols may be more successful.

Related

diabetes mellitus type 1 (insulin-dependent, juvenile) islet cell

Specific

donislecel-jujn (Lantidra)

General

pancreatic transplantation cell transplantation

References

  1. Journal Watch 20(17):133, 2000 - Shapiro et al N Engl J Med - Robertson N Engl J Med 343:289, 2000
  2. Shapiro AM et al, International trial of the Edmonton Protocol for Islet transplantation. N Engl J Med 355:1372 PMID: 17005949 - Bromberg JS and LeRoith D Diabetes Cure -- Is the glass half full? N Engl J Med 355:1318 PMID: 17005956
  3. Mallapaty S Stem cells reverse woman's diabetes - a world first She is the first person with type 1 diabetes to receive this kind of transplant. Nature. Sept 26, 2024 https://www.nature.com/articles/d41586-024-03129-3 - Wang S, Du Y, Zhang B et al Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient. Cell. 2024 Sep 20:S0092-8674(24)01022-5. PMID: 39326417 https://www.cell.com/cell/abstract/S0092-8674(24)01022-5
  4. Wu J, Li T, Guo M et al Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue. Cell Discov. 2024 Apr 30;10(1):45. PMID: 38684699 PMCID: PMC11058776 Free PMC article. No abstract available.
  5. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Pancreatic Islet Transplantation https://www.niddk.nih.gov/health-information/diabetes/overview/insulin-medicines-treatments/pancreatic-islet-transplantation