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pANCA (anti-myeloperoxidase, anti-leukocyte elastase)

Also see pANCA in serum Etiology: 1) directed against myeloperoxidase a) Churg-Strauss syndrome (60-70%) b) microscopic polyangiitis (75-80%) c) idiopathic crescentic glomerulonephritis (80%) d) polyarteritis nodosa [3,4] e) Wegener's granulomatosis (20%) 2) directed against leukocyte elastase, lactoferrin a) vasculitis b) primary sclerosing cholangitis (60-85%) c) ulcerative colitis (60-75%) d) primary biliary cirrhosis (30-40%) e) rheumatoid arthritis 1] with Felty's syndrome (90-100%) 2] with vasculitis (50-75%) 3] uncomplicated (20-40%) f) systemic lupus erythematosus (25%) g) drug-induced lupus erythematosus - minocycline, hydralazine [5] h) 5% of normal subjects 3) p-ANCA may also be positive in: a) autoimmune chronic hepatitis b) hepatitis C c) sulfasalazine toxicity d) Crohn's disease (10-20%) e) juvenile chronic polyarthritis (10-20%) f) ankylosing spondylitis (10-20%) g) psoriatic arthritis (10-20%) Pathology: - autoantibody directed against myeloperoxidase or against leukocyte elastase (proteinase-3), lactoferrin Compartment: - perinuclear

Related

elastase-2; neutrophil elastase; leukocyte elastase; medullasin; bone marrow serine protease ( ELA2, ELANE) lactotransferrin; lactoferrin; talalactoferrin; contains: kaliocin-1; lactoferroxin-A; lactoferroxin-B; lactoferroxin-C (LTF, LF) myeloperoxidase (MPO) myeloperoxidase antibody in body fluid neutrophil or polymorphonuclear leukocyte (PMN, poly) pANCA in serum; anti-myeloperoxidase in serum; anti-leukocyte elastase in serum

Specific

lactoferrin antibody in serum

General

anti-neutrophil cytoplasmic antibody (ANCA)

References

  1. Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed, WB Saunders, Philadelphia 1995
  2. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 782, 847
  3. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1913
  4. Kaiser Permanente Northern Calfornia Regional Laboratory
  5. Medical Knowledge Self Assessment Program (MKSAP) 11, 16, 17. American College of Physicians, Philadelphia 1998, 2012, 2015
  6. Bosch X et al, Antineutrophil cytoplasmic antibodies. Lancet 2006, 368:404 PMID: 16876669
  7. Panel of 3 tests Laboratory Test Directory ARUP: 50567