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palbociclib (Ibrance)
Indications:
- metastatic breast cancer* in postmenopausal women
* doubles time to progression or death [1]
* intended for postmenopausal women with estrogen receptor- positive, HER2-negative metastatic breast cancer who have not received endocrine-based therapy
* also indicated for recurrent metastatic estrogen receptor-positive, HER2-negative breast cancer after prior aromatase inhibitor therapy [3]
* used in combination with letrozole
Adverse effects:
- bone marrow suppression [2]
- leukopenia, neutropenia, anemia, thrombocytopenia
- nausea, vomiting, diarrhea
- stomatitis
- alopecia
- fatigue, asthenia, anorexia
- peripheral neuropathy
- upper respiratory tract infection
- epistaxis [2]
Mechanism of action:
- cyclin-dependent kinase inhibitor (CDK4/CDK6 inhibitor) [1]
Notes:
- FDA-approved (Feb 2015)
Interactions
drug interactions
Related
abemaciclib (Verzenio)
General
small inhibitory antineoplastic agent (ib drug)
cyclin-dependent kinase inhibitor (CDKI, CDKN)
Database Correlations
PUBCHEM correlations
References
- Finn RS et al
Final results of a randomized Phase II study of PD 0332991, a
cyclin-dependent kinase (CDK)-4/6 inhibitor, in combination
with letrozole vs letrozole alone for first-line treatment of
ER+/HER2- advanced breast cancer (PALOMA-1; TRIO-18).
American Association for Cancer Research. 2014 Annual Meeting.
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=3404&sKey=113bcbb9-585d-4939-b5de-99e11e302ef2&cKey=54090e4a-2f25-4594-83b3-37e21e120e6b&mKey=6ffe1446-a164-476a-92e7-c26446874d93
- FDA News Release. February 3, 2015
FDA approves Ibrance for postmenopausal women with advanced
breast cancer
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm432871.htm
- Medical Knowledge Self Assessment Program (MKSAP) 18,
American College of Physicians, Philadelphia 2018
- Turner NC, Ro J, Andre F et al for the PALOMA3 Study Group.
Palbociclib in Hormone-Receptor-Positive Advanced Breast Cancer.
N Engl J Med. 2015 Jul 16;373(3):209-19.
PMID: 26030518 Free Article