p21 (CDKN1A)-activated kinase (PAK)

Function: - Rho family GTPases bind to & activate PAKs - PAK proteins have been implicated as downstream effectors linking Rho GTPases to the actin cytoskeleton & to effectors of MAP kinase cascades, including JNK1 & MAP kinase p38 alpha

Specific

p21 Cdc42(rho-G)/Rac-associated kinase, PAK1, p65PAK or alpha-PAK p21-activated kinase 2 (PAK2), S6/H4 kinase, PAK65 or gamma-PAK p21-activated kinase 3 (PAK3), beta-PAK or oligophrenin-3 p21-activated kinase 4 (PAK4, serine/threonine protein kinase PAK 4, KIAA1142) p21-activated kinase 5; p21-activated kinase 7; serine/threonine protein kinase PAK5; p21-activated kinase 7 (PAK7, PAK5) p21-activated kinase 6 (PAK6)

Properties

STATE: active state MOTIF: S/T phosphorylation site kinase domain MOTIF: ATP-binding site NAME: ATP-binding site

References

OMIM :accession 300142