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19S proteasome (PA700 complex)

Function: - two 19S regulatory caps at the end of the 20S proteasome barrel form the 26S proteasome - the 19S caps mediate recognition of polyubiquitin & unfold the target protein for degradation - activates proteolytic activity of 20S proteasome Structure: - consists of 28 subunits arranged to form a cylinder-shaped complex by 4 stacked rings, each containing 7 subunits

General

macromolecular complex

Properties

MISC-INFO: SEDIMENTATION_COEFFICIENT 19 S

References

  1. Kosik KS, Shimura H. Phosphorylated tau and the neurodegenerative foldopathies. Biochim Biophys Acta. 2005 Jan 3;1739(2-3):298-310. Epub 2004 Nov 26. Review. PMID: 15615647
  2. UniProt :accession Q14669

Component-of

26S proteasome

Components

26S protease regulatory subunit-4 (PSMC1) 26S protease subunit-6 (TAT-binding protein-7, TBP-7, PSMC4) 26S proteasome regulatory subunit 12 (26S proteasome subunit p55, non-ATPase subunit 12, PSMD12) 26S proteasome regulatory subunit 13 (26S proteasome subunit p40.5, non-ATPase subunit 13, PSMD13) 26S proteasome alpha subunit 7; proteasome subunit RC6-1; proteasome subunit XAPC7 (PSMA7) 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2, 26S proteasome regulatory subunit S1, 26S proteasome subunit p112, PSMD1) 26S proteasome non-ATPase regulatory subunit 14 (PSMD14, 26S proteasome regulatory subunit rpn11, 26S proteasome-associated PAD1 homolog 1, POH1) 26S proteasome regulatory subunit 10 (26S proteasome subunit p28, non-ATPase subunit 10, PSMD10, gankyrin) 26S proteasome regulatory subunit 11 (26S proteasome subunit p44.5, non-ATPase subunit 11, PSMD11) 26S proteasome regulatory subunit 6 (26S proteasome subunit p42A, non-ATPase subunit 6, 26S proteasome regulatory subunit S10, phosphonoformate immuno-associated protein 4, proteasome regulatory particle subunit p44S10, breast cancer-associated protein SGA-113M, PSMD6, KIAA0107, PFAAP4) 26S proteasome regulatory subunit 9 (26S proteasome subunit p27, non-ATPase subunit 9, PSMD9) 26S proteasome regulatory subunit S10B (26S proteasome subunit p42, proteasome 26S subunit ATPase 6, PSMC6, SUG2) 26S proteasome regulatory subunit S12 (26S proteasome subunit p40, MOV34 protein, PSMD7, 26S proteasome subunit non ATPase 7, Moloney leukemia virus 34 proviral integration site mouse homolog) 26S proteasome regulatory subunit S14 (26S proteasome non-ATPase regulatory subunit 8, 26S proteasome subunit p31, PSMD8) 26S proteasome regulatory subunit S2 (26S proteasome subunit p97, TNF type 1 receptor associated protein 2, 55.11 protein, PSMD2, TRAP2) 26S proteasome regulatory subunit S3 (26S proteasome subunit p58, PSMD3) 26S proteasome regulatory subunit S5A (26S proteasome non-ATPase regulatory subunit 4, Rpn10, multiubiquitin chain binding protein, antisecretory factor-1, AF, ASF, PSMD4, MCB1) 26S proteasome regulatory subunit S5B (26S protease subunit S5 basic, HA1357, PSMD5, KIAA0072) proteasome subunit alpha type 7-like (PSMA8, PSMA7L)