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positive transcription elongation factor B (P-TEFB, CDK9/cyclin T complex)

Function: - facilitates transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase 2 (RNAP2) - forms a complex with AFF4/AF5Q31 - interacts with DSIF complex Structure: - subunits: CDK9, cyclin-T (CCNT1 or CCNT2)

Related

elongin (SIII, transcription elongation factor B, TEFB)

General

molecular complex

Properties

SUBUNITS: cyclin T (positive transcription elongation factor B, P-TEFB) MOTIF: ubiquitination site (destruction box, D-box) SITE: N-TERMINAL FOR-BINDING-OF: ubiquitin PEST region cyclin box FOR-BINDING-OF: cyclin-dependent kinase cyclin-dependent kinase-9 (CDK9) STATE: active state MOTIF: kinase domain SITE: 19-315 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 25-33 ATP-binding site NAME: ATP-binding site SITE: 48-48 aspartate residue {D149} Thr phosphorylation site {T186}

References

  1. UniProt :accession O60563
  2. UniProt :accession O60583

Components

cyclin T (positive transcription elongation factor B, P-TEFB) cyclin-dependent kinase-9 (CDK9, serine/threonine protein kinase PITALRE, CDC2L4)