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ribosomal protein S6 kinase beta-1; ribosomal protein S6 kinase I; S6K1; S6K; 70 kD ribosomal protein S6 kinase 1; p70 S6 kinase alpha; p70(S6K)-alpha; p70-S6K; P70S6K; p70-alpha (RPS6KB1, STK14A)
Function:
- specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens
- interacts with PPP1R9A/neurabin-1 (putative)
- activation by serine/threonine phosphorylation & protein kinase C
- inactivated by type 2A phosphatase
- apparently not a substrate for MAP kinase
- interacts with PPP1R9A/neurabin-1 (putative)
Structure:
- belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
- contains 1 AGC-kinase C-terminal domain
- contains 1 protein kinase domain
Compartment:
- cytoplasm, cell junction, synapse, synaptosome (putative)
Alternative initiation: Named isoforms=2
Expression:
- widely expressed
General
ribosomal protein S6 kinase
Properties
SIZE: entity length = 525 aa
MW = 59 kD
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: kinase domain
SITE: 91-352
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 97-105
ATP-binding site
NAME: ATP-binding site
SITE: 123-123
aspartate residue {D218}
AGC-kinase C-terminal {353-423}
Ser phosphorylation site {S441}
Thr phosphorylation site {T444}
Ser phosphorylation site {S447}
Database Correlations
OMIM 608938
UniProt P23443
PFAM correlations
Entrez Gene 6198
Kegg hsa:6198
ENZYME 2.7.11.1
References
- UniProt :accession P23443
- Denton RM.
Insulin signalling: search for the missing links.
Nature. 1990 Nov 22;348(6299):286-7.
PMID: 2250701