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p53 gene

The most frequently mutated tumor suppressor gene is the p53 gene, mutated in roughly 50% of tumors, including sporadic osteosarcomas, soft tissue sarcomas, brain tumors, leukemias, & lung carcinoma & breast carcinoma

Related

cellular tumor antigen p53; tumor suppressor p53, phosphoprotein p53; antigen NY-CO-13 (TP53, p53)

General

tumor suppressor gene or anti-oncogene

Properties

TEMPLATE-FOR: messenger RNA TEMPLATE-FOR: cellular tumor antigen p53 LOCUS: human chromosome-17 P13.105-12 MOTIF: maf recognition element NAME: maf recognition element FOR-BINDING-OF: maf family protein transcriptional start site exon intron transcriptional termination site

Database Correlations

OMIM 191170 MORBIDMAP 191170

References

  1. Malkin et al Science 250:1233 1990
  2. Harris Science 262:1980 1993
  3. Dhakshinamoorthy S & Jaiswal AK, Oncogene 21:5301, 2002