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P504S+p63+cytokeratin 903 Ag in tissue
Indications:
- evaluation of prostate cancer
* occasional benign glands, high-grade prostatic intraepithelial neoplasia, atypical adenomatous hyperplasia, & urothelial carcinoma may express P504S [2]
* 504S is best used only in conjunction with strict light microscopy correlation & preferably with high molecular weight cytokeratin immunostaining [2]
Related
cytokeratin, epithelial keratins or soft alpha-keratins
p63 protein; p53 homolog p63; tumor protein p73-like; p73L; TP63; p51; p40; keratinocyte transcription factor KET; chronic ulcerative stomatitis protein (CUSP, TP73L, KET, p63, P73H)
prostate cancer
General
P504S Ag in tissue
p63 Ag in tissue
cytokeratin Ag in tissue
References
- Jiang Z, Woda BA, Rock KL et al
P504S: a new molecular marker for the detection of prostate
carcinoma.
Am J Surg Pathol. 2001 Nov;25(11):1397-404.
PMID: 11684956
- Beach R, Gown AM, De Peralta-Venturina MN et al
P504S immunohistochemical detection in 405 prostatic specimens
including 376 18-gauge needle biopsies.
Am J Surg Pathol. 2002 Dec;26(12):1588-96.
PMID: 12459625