Search
alpha-2-macroglobulin receptor-associated protein; alpha-2-MRAP; low density lipoprotein receptor-related protein-associated protein 1; RAP; p39RAP (LRPAP1, A2MRAP)
Function:
- interacts with LRP1/alpha-2-macroglobulin receptor & glycoprotein 330
- present on cell surface forming a complex with LRP1 heavy & light chains
- binds LRP1B
- binding is followed by internalization & degradation
- may serve as a chaperone for the LRP1
- p39rap modifies (inhibits) binding of ligands to the 515 KD subunit of LRP
Structure:
- N-glycosylated
- belongs to the alpha-2-MRAP family
Compartment:
- endoplasmic reticulum. cytoplasm, cell surface
- intracellular & associated with cell surface receptors
- found in the endoplasmic reticulum
Pathology:
- in complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membranous glomerulonephritis
Related
CD91, low density lipoprotein (LDL) receptor related protein (LRP) 1, apolipoprotein E [apoE] receptor 1, chylomicron remnant receptor or alpha-2 macroglobulin receptor
General
glycoprotein
Properties
SIZE: entity length = 357 aa
MW = 41 kD
COMPARTMENT: cytoplasm
endoplasmic reticulum
MOTIF: signal sequence {1-34}
coiled coil {219-310}
binding site
SITE: 237-353
FOR-BINDING-OF: low-density lipoprotein receptor
MOTIF: N-glycosylation site {N268}
ER retention {354-357}
Database Correlations
OMIM 104225
UniProt P30533
PFAM correlations
Kegg hsa:4043
References
- UniProt :accession P30533
- Williams SE et al
A novel mechanism for controlling the activity of alpha
2-macroglobulin receptor/low density lipoprotein receptor-
related protein. Multiple regulatory sites for 39-kDa
receptor-associated protein.
J Biol Chem 267:9035 1992
PMID: 1374383