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p38MAPK subfamily
Function:
1) roles in inflammation
2) roles in stress responses
3) roles in apoptosis
4) differentiation
a) adipocytes
b) cardiomyocytes
c) erythroblasts
d) myoblasts
e) neurons
5) proliferation
a) fibroblasts
b) hematopoietic cells
6) cell survival
a) cardiomyocytes
b) fibroblasts
c) neurons
7) SB203580 inhibits p38MAPK-alpha & p38MAPK-beta
8) SB203580 does not inhibit p38MAPK-gamma or p38MAPK-delta
Comparative biology:
- p38MAPK family members affect development & oogenesis in drosophila
Pharmacology:
- anti-inflammatory agent losmapimod inhibits p38MAPKs
Interactions
molecular events
Specific
mitogen-activated protein kinase 11; mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; p38-2; stress-activated protein kinase 2 (MAPK11, PRKM11, SAPK2)
mitogen-activated protein kinase 12; extracellular signal-regulated kinase 6; ERK-6; ERK5; stress-activated protein kinase 3; mitogen-activated protein kinase p38 gamma; MAP kinase p38 gamma (MAPK12, ERK6, SAPK3)
mitogen-activated protein kinase 13; stress-activated protein kinase 4; mitogen-activated protein kinase p38 delta; MAP kinase p38 delta (MAPK13, PRKM13, SAPK4)
mitogen-activated protein kinase 14; mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAX-interacting protein 2; MAP kinase MXI2; SAPK2A (MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2)
General
mitogen-activated protein kinase (MAP kinase) or microtubule-associated protein kinase
Figures/Diagrams
MAP kinase pathways
Properties
SIZE: MW = 42-44 kD
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: Thr-phosphate
Tyr-phosphate
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
References
- Nebreda AR, Porras A.
p38 MAP kinases: beyond the stress response.
Trends Biochem Sci. 2000 Jun;25(6):257-60. Review.
PMID: 10838561