P2Y12 purinoceptor; P2Y purinoceptor 12; P2Y12; P2Y12 platelet ADP receptor; P2Y(ADP); ADP-glucose receptor; ADP receptor P2Y12; ADPG-R; P2Y(AC); P2Y(cyc); P2T(AC); SP1999 (P2RY12, HORK3)

Function: - receptor for ADP & ATP - coupled to G-proteins that inhibit the adenylyl cyclase second messenger system - not activated by UDP & UTP - involved in platelet aggregation Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - highly expressed in platelets - lower levels in the brain - lowest levels in the lung, appendix, pituitary & adrenal gland - expressed in the spinal cord & in fetal brain Pathology: - defects in P2RY12 are a cause of bleeding disorder Pharmacology: - target of antiplatelet agents ticagrelor, clopidogrel & prasugrel

General

adenosine diphosphate [ADP] receptor glycoprotein P2Y purinoceptor or P2Y purinergic receptor

Properties

SIZE: entity length = 342 aa MW = 39 kD COMPARTMENT: plasma membrane CELL: monocyte MOTIF: exoplasmic domain {1-25} MOTIF: N-glycosylation site {N6} N-glycosylation site {N13} transmembrane domain {26-46} cytoplasmic loop {47-58} transmembrane domain {59-79} exoplasmic loop {80-99} MOTIF: cysteine residue {C97} MODIFICATION: cysteine residue {C175} transmembrane domain {100-120} cytoplasmic loop {121-142} transmembrane domain {143-163} exoplasmic loop {164-191} MOTIF: cysteine residue {C175} MODIFICATION: cysteine residue {C97} transmembrane domain {192-212} cytoplasmic loop {213-233} transmembrane domain {234-254} exoplasmic loop {255-281} transmembrane domain {282-302} cytoplasmic domain {303-342}

Database Correlations

OMIM correlations UniProt Q9H244 Pfam PF00001 Kegg hsa:6480

References

UniProt :accession Q9H244