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P2Y11 purinoceptor; P2Y purinoceptor 11; P2Y11 (P2RY11)
Function:
- receptor for ATP & ADP
- coupled to G-proteins that activate both phosphatidylinositol-Ca+2 & adenylyl cyclase second messenger systems
- not activated by UTP or UDP
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane; multi-pass membrane protein
Expression:
- highest expression in spleen, lower in small intestine
- expression increased by DMSO & retinoic acid
Genetics:
- a putative trans-splicing which involves PPAN & P2RY11 gene regions produces a fusion protein
General
glycoprotein
P2Y purinoceptor or P2Y purinergic receptor
Properties
SIZE: entity length = 374 aa
MW = 40 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-29}
MOTIF: N-glycosylation site {N4}
transmembrane domain {30-50}
cytoplasmic loop {51-64}
transmembrane domain {65-85}
exoplasmic loop {86-116}
MOTIF: cysteine residue {C102}
MODIFICATION: cysteine residue {C180}
transmembrane domain {117-137}
cytoplasmic loop {138-146}
transmembrane domain {147-167}
exoplasmic loop {168-206}
MOTIF: N-glycosylation site {N179}
cysteine residue {C180}
MODIFICATION: cysteine residue {C102}
transmembrane domain {207-227}
cytoplasmic loop {228-245}
transmembrane domain {246-266}
exoplasmic loop {267-308}
transmembrane domain {309-329}
cytoplasmic domain {330-374}
Database Correlations
OMIM 602697
UniProt Q96G91
Pfam PF00001
Kegg hsa:5032
References
UniProt :accession Q96G91