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P2Y1 purinoceptor; P2Y purinoceptor 1; P2Y1; G-protein coupled purinergic receptor P2Y1 (P2RY1)
Function:
- receptor for extracellular adenine nucleotides including ATP & ADP
- in platelets, binding to ADP leads to mobilization of intracellular Ca+2 via activation of phospholipase C, a change in platelet shape, & probably to platelet aggregation
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P & A2P5P; these inhibit Ca+2 mobilization & shape change in platelets
General
glycoprotein
P2Y purinoceptor or P2Y purinergic receptor
phosphoprotein
Properties
SIZE: entity length = 373 aa
MW = 42 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-52}
MOTIF: N-glycosylation site {N11}
N-glycosylation site {N27}
transmembrane domain {53-74}
cytoplasmic loop {75-87}
transmembrane domain {88-109}
exoplasmic loop {110-126}
MOTIF: N-glycosylation site {N113}
cysteine residue {C124}
MODIFICATION: cysteine residue {C202}
transmembrane domain {127-147}
cytoplasmic loop {148-166}
transmembrane domain {167-188}
exoplasmic loop {189-218}
MOTIF: N-glycosylation site {N197}
cysteine residue {C202}
MODIFICATION: cysteine residue {C124}
transmembrane domain {219-238}
cytoplasmic loop {239-265}
transmembrane domain {266-285}
exoplasmic loop {286-303}
transmembrane domain {304-328}
cytoplasmic domain {329-373}
MOTIF: Ser phosphorylation site {S352}
Ser phosphorylation site {S354}
Database Correlations
OMIM 601167
UniProt P47900
Pfam PF00001
Kegg hsa:5028
References
UniProt :accession P47900