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cytochrome b558 alpha subunit (p22 phagocyte B-cytochrome, neutrophil cytochrome B, 22 kD polypeptide, p21/p22phox, superoxide-generating NADPH oxidase light chain subunit, CYBA)
Function:
- alpha subunit of cytochrome b558
- component of the membrane-bound oxidase of phagocytes (NADPH oxidase) that generates superoxide
- associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide
- composed of a heavy chain (beta) & a light chain (alpha)
- interacts with DUOX1, DUOX2 & TPO
- interacts with NOX3 & NOX4
Structure:
- belongs to the p22phox family
- heme prosthetic group could be coordinated with residues of the light chain, the heavy chain, or both
Pathology:
- defects in CYBA are a cause of autosomal recessive chronic granulomatous disease
Related
chronic granulomatous disease
General
protein subunit
Properties
SIZE: MW = 21-22 kD
MOTIF: transmembrane domain
Iron [Fe]-binding site
SITE: 93-93
proline-rich region
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM correlations
MORBIDMAP 608508
UniProt P13498
Pfam PF05038
References
- Rotrosen D, Yeung CL, Leto TL, Malech HL, Kwong CH.
Cytochrome b558: the flavin-binding component of the phagocyte
NADPH oxidase.
Science. 1992 Jun 5;256(5062):1459-62.
PMID: 1318579
- Segal AW, Abo A.
The biochemical basis of the NADPH oxidase of phagocytes.
Trends Biochem Sci. 1993 Feb;18(2):43-7. Review.
PMID: 8488557
- Pawson T
Protein modules and signalling networks
Nature 373:573 1995
PMID: 7531822
- CYBAbase; CYBA mutation db
http://bioinf.uta.fi/CYBAbase/
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CYBA
- SHMPD; The Singapore human mutation & polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=C&genename=CYBB+%40+GP91-PHOX
- UniProt :accession P13498
Component-of
cytochrome b558