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ozenoxacin (Xepi)
Indications:
- treatment of impetigo caused by Staphylococcus aureus or Streptococcus pyogenes in adults or children >= 2 years
Dosage:
- apply a thin layer topically to affected area q12hr for 5 days
- not to exceed 100 cm2 area in adults & adolescents or 2% of body surface area for children age 2 months to 12 years
Cream: 1%
Mechanism of action:
- quinolone antimicrobial
- inhibits bacterial DNA replication enzymes, DNA gyrase A, & topoisomerase IV
General
topical agent
quinolone antibiotic
Database Correlations
PUBCHEM cid=9863827
References
- Windle ML.
FDA New Drug and Biologic Approvals -- 2017 Year-in-Review
Medscape - Jan 11, 2018.
https://reference.medscape.com/viewarticle/890871
- U.S. Food and Drug Administration.
Novel Drug Approvals for 2017.
https://www.fda.gov/Drugs/DevelopmentApprovalProcess/DrugInnovation/ucm537040.htm
- Gropper S, Albareda N, Chelius K et al
Ozenoxacin 1% cream in the treatment of impetigo: a multicenter,
randomized, placebo- and retapamulin-controlled clinical trial.
Future Microbiol. 2014;9(9):1013-23.
PMID: 25340832
- Gropper S, Cepero AL, Santos B, Kruger D.
Systemic bioavailability and safety of twice-daily topical
ozenoxacin 1% cream in adults and children with impetigo.
Future Microbiol. 2014;9(8 Suppl):S33-40.
PMID: 25209523
- Gropper S, Albareda N, Santos B, Febbraro S.
Skin tissue exposure of once- versus twice-daily topical
ozenoxacin 2% cream: a Phase I study in healthy volunteers.
Future Microbiol. 2014;9(8 Suppl):S17-22.
PMID: 25209520
- Gropper S, Albareda N, Santos B, Febbraro S.
Systemic bioavailability, safety and tolerability of topical
ozenoxacin in healthy adult volunteers.
Future Microbiol. 2014;9(8 Suppl):S11-6.
PMID: 5209519
- Gropper S, Cepero AL, Dosik JS et al
Cumulative irritation, sensitizing potential, phototoxicity
and photoallergy of ozenoxacin in healthy adult volunteers.
Future Microbiol. 2014;9(8 Suppl):S23-31.
PMID: 25209521
- Santos B, Ortiz J, Gropper S.
In vitro percutaneous absorption and metabolism of ozenoxacin in excised human skin.
Future Microbiol. 2014;9(8 Suppl):S3-9.
PMID: 25209522