oxytocin receptor; OT-R (OXTR)

Function: - receptor for oxytocin - activity is mediated by G proteins which activate a phosphatidylinositol-Ca⁺² second messenger system Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 389 aa MW = 43 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-38} MOTIF: N-glycosylation site {N8} N-glycosylation site {N15} N-glycosylation site {N26} transmembrane domain {39-63} cytoplasmic loop {64-74} transmembrane domain {75-97} exoplasmic loop {98-113} MOTIF: cysteine residue {C112} MODIFICATION: cysteine residue {C187} transmembrane domain {114-135} cytoplasmic loop {136-154} transmembrane domain {155-175} exoplasmic loop {176-202} MOTIF: cysteine residue {C187} MODIFICATION: cysteine residue {C112} transmembrane domain {203-225} cytoplasmic loop {226-275} transmembrane domain {276-294} exoplasmic loop {295-309} transmembrane domain {310-332} cytoplasmic domain {333-389}

Database Correlations

OMIM 167055 UniProt P30559 Pfam PF00001 Kegg hsa:5021