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oxysterol; hydroxysterol

Function: - endogenous ligands of LXR-alpha & LXR-beta - modulators of cholesterol biosynthesis & other processes - inhibition HMG CoA reductase (highly purified cholesterol does not) - induction of apoptosis - calcification of vascular cells * All oxysterols may not have all functions*

Related

hydroxymethylglutaryl [HMG] CoA reductase (HMGCR) LX nuclear receptor (LXR, oxysterol receptor) oxidized low density lipoprotein (oxidized LDL, oxLDL) oxysterol-binding protein (OSBP)

Specific

22-OH-cholesterol 24,25-cholesterol epoxide 24-OH-cholesterol 25-OH-cholesterol 27-OH-cholesterol 7-ketocholesterol; 7-oxocholesterol 7-OH-cholesterol cholesterol ozonolysis metabolite 1 cholesterol ozonolysis metabolite 2 salinomycin; salinomycinum (Coxistac)

General

sterol

References

  1. Schroepfer GJ Jr. Oxysterols: modulators of cholesterol metabolism and other processes. Physiol Rev. 2000 Jan;80(1):361-554. Review. PMID: 10617772