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oxidized low density lipoprotein (oxidized LDL, oxLDL)
Function:
1) recognized & degraded by OLR1
2) recognized by C-type lectin domain of OLR1
3) may mediate response to fluid shear stress
Pathology:
1) marker of atherosclerosis
2) induces vascular endothelial cell activation & dysfunction pro-inflammatory responses, pro-oxidative conditions & apoptosis
3) oxidized choline glycerophospholipids activate platelet CD36, promote platelet activation, impair endothelial function & increase foam cell concentration within atherosclerotic plaques [2]
Laboratory:
- LDL oxidized in serum/plasma
- LDL oxidized Ab in serum
Related
oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; lectin-type oxidized LDL receptor 1; lectin-like oxidized LDL receptor 1; lectin-like oxLDL receptor 1; LOX-1; hLOX-1 (OLR1, LOX1)
oxysterol; hydroxysterol
General
low density lipoprotein (LDL, beta-lipoprotein)
Properties
SIZE: WIDTH = 20-23 NM
COMPARTMENT: plasma
References
- OMIM :accession 600168
- Podrez EA, Byzova TV, Febbraio M, Salomon RG, Ma Y,
Valiyaveettil M, Poliakov E, Sun M, Finton PJ, Curtis BR,
Chen J, Zhang R, Silverstein RL, Hazen SL.
Platelet CD36 links hyperlipidemia, oxidant stress and a
prothrombotic phenotype.
Nat Med. 2007 Sep;13(9):1086-95. Epub 2007 Aug 26.
PMID: 17721545
- Jackson SP, Calkin AC.
The clot thickens-oxidized lipids and thrombosis.
Nat Med. 2007 Sep;13(9):1015-6.
PMID: 17828215
http://jama.ama-assn.org/cgi/content/full/297/5/499
Components
apolipoprotein B100 (apoB100)
cholesterol
cholesterol ester
phosphatidylcholine (lecithin)
triglyceride