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oxaliplatin (Eloxatin)

Indications: - metastatic colorectal carcinoma - pancreatic adenocarcinoma [3] - testicular cancer [3] Adverse effects: - neurotoxicity related to cold - distal sensory neuropathy Mechanism of action: - platinum complexes bind to & crosslink of DNA, which triggers apoptosis

Interactions

drug adverse effects of platinum-based chemotherapy

General

antineoplastic platinum complex; platinum-based chemotherapy

References

  1. Department of Veterans Affairs, VA National Formulary - non formulary drug request
  2. Medical Knowledge Self Assessment Program (MKSAP) 16, American College of Physicians, Philadelphia 2012
  3. Deprecated Reference

Component-of

5-fluorouracil/irinotecan/leucovorin/oxaliplatin (FOLFIRINOX) 5-fluorouracil/oxaliplatin/leucovorin (FOLFOX) capecitabine/oxaliplatin (Xelox, Cape-Ox CAPOX) 5-fluorouracil/oxaliplatin/leucovorin (FOLFOX)