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oxacillin

2nd generation penicillin. Indications: - bacterial infections due to susceptible organisms - skin or soft tissue infections [3] - osteomyelitis - empiric treatment for fever of unknown origin [3] Dosage: - 1-2 g IV/IM every 4-6 hours. - Pediatrics: 50-100 mg/kg/day. - 500-1000 mg PO every 4-6 hours. - Pediatrics: 5- mg/kg/day divided every 4-6 hours Tabs: 250 & 500 mg. Suspension: 250 mg/5 mL. Antimicrobial activity: 1) Staphylococcus aureus - not methicillin-resistant S aureus {MRSA}) 2) less active than other penicillins against Streptococcus sp. 3) lacks enterococcus & anaerobic coverage Adverse effects: - hypersensitivity - skin rash - fever - hepatitis Mechanism of action: 1) inhibition of bacterial wall synthesis 2) active against penicillinase-producing organisms

Interactions

drug interactions

General

2nd generation penicillin (penicillinase-resistant)

Properties

MISC-INFO: elimination route KIDNEY pregnancy-category B safety in lactation ?

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Harrison's Principles of Internal Medicine, 13th ed. Companion Handbook. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1995, pg 161.
  3. Deprecated Reference