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CD200; OX-2 membrane glycoprotein (CD200, MOX1, MOX2, My033)
Function:
- costimulates T-cell proliferation
- may regulate myeloid cell activity in a variety of tissues
- interacts with CD200R1
Structure:
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: cell membrane; single-pass type 1 membrane protein
Alternative splicing: named isoforms=2
Related
CD200 cell surface glycoprotein receptor (cell surface glycoprotein OX2 receptor, CD200 receptor, Mox2 receptor, CD200R1, CD200R, CRTR2, MOX2R, OX2R)
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
membrane protein
Properties
SIZE: entity length = 278 aa
MW = 31 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-30}
immunoglobulin superfamily domain {31-141}
MOTIF: cysteine residue {C51}
MODIFICATION: cysteine residue {C121}
N-glycosylation site {N95}
N-glycosylation site {N103}
N-glycosylation site {N110}
cysteine residue {C121}
MODIFICATION: cysteine residue {C51}
immunoglobulin superfamily domain {142-232}
MOTIF: N-glycosylation site {N157}
cysteine residue {C160}
MODIFICATION: cysteine residue {C214}
N-glycosylation site {N181}
N-glycosylation site {N190}
cysteine residue {C214}
MODIFICATION: cysteine residue {C160}
transmembrane domain {233-259}
Database Correlations
OMIM 155970
UniProt P41217
Pfam PF00047
Entrez Gene 4345
References
- UniProt :accession P41217
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org//genes/CD200ID44381ch3q13.html