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Ovral (ethinyl estradiol/norgestrel)
50 ug ethinyl estradiol (estrogen) plus 0.5 mg norgestrel (progestin)
Indications:
- postcoital contraception (morning after pill)
* levonorgestrel 1.5 mg (One Step now advertised on WebMD) & ulipristal are used [3] (see morning after pill)
Contraindications:
pregnancy-category X
safety in lactation -
Dosage:
1) 2 tablets at 1st visit
2) 2 tablets 12 hours later
Pharmacokinetics: elimination: liver
Adverse effects:
1) common (> 10%)
- nausea, peripheral edema, breast enlargement, breast tenderness, anorexia, bloating
2) not common (1-10%)
- vomiting, diarrhea, increased libido, headache
3) uncommon (< 1%)
- intolerance to contact lenses, breast tumors, amenorrhea, alterations in mestrual flow, hypertension, thromboembolism, stroke, myocardial infarction, edema, depression, dizziness, anxiety, chloasma, melasma, rash, hyperglycemia, GI distress, increased serum triglycerides, increased LDL, cholestatic jaundice, increased susceptibility to Candida infection
Drug interactions:
- barbiturates, carbamazepine, cyclosporine, griseofulvin, penicillins, phenytoin, rifampin, tetracyclines
Interactions
drug adverse effects of estrogens
General
monophasic oral contraceptive
ethinyl estradiol/norgestrel
References
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- WebMD
Plan B One-Step
http://www.webmd.com/sex/birth-control/plan-b#1
- Locke T for Medscape. Sept 21, 2016
Emergency Contraceptives Affected by Other Medications,
UK Warns.
http://www.medscape.com/viewarticle/869116