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ovariectomy (oophorectomy)
Surgical removal of one or both ovaries.
Indications:
- prophylactic bilateral salpingo-oophorectomy (BSO), with or without hysterectomy, after completion of childbearing is the standard of care for female carriers of BRCA1 mutation or BRCA2 mutation [4]
Complications:
- increased risk of Parkinson's disease [1] (RR = 1.8)
- increased risk of cognitive impairment [2] (RR = 1.6)
- increased risk of cardiovascular disease [3]
a) coronary artery disease & myocardial infarction [5]
b) stroke [5]
- increased risk of chronic renal failure [6]
- increased all-cause mortality [5]
Specific
salpingo-oophorectory
General
gynecologic surgery
surgical resection (excision)
References
- Rocca WA et al,
Increased risk of parkinsonism in women who underwent
oophorectomy before menopause.
Neurology 2007, 69:(EPub)
PMID: 17761549
- Rocca WA et al,
Increased risk of cognitive impairment of dementia in women
who underwent oophorectomy before menopause.
Neurology 2007, 69:1074
PMID: 17761551
- Rivera CM et al
Increased cardiovascular mortality after early bilateral
oophorectomy.
Menopause 2009 Jan/Feb; 16:15.
PMID: 19034050
- Parker WH and Manson JE.
Oophorectomy and cardiovascular mortality:
Is there a link?
Menopause 2009 Jan/Feb; 16:1.
PMID: 18971791
- Rebbeck TR et al.
Meta-analysis of risk reduction estimates associated with
risk-reducing salpingo-oophorectomy in BRCA1 or BRCA2
mutation carriers.
J Natl Cancer Inst 2009 Jan 21; 101:80.
PMID: 19141781
- Greene MH and Mai PL.
What have we learned from risk-reducing salpingo-oophorectomy?
J Natl Cancer Inst 2009 Jan 21; 101:70.
PMID: 19141782
- Parker WH et al
Ovarian conservation at the time of hysterectomy and
long-term health outcomes in the Nurses' Health Study.
Obstet Gynecol 2009 May; 113:1027.
PMID: 19384117
- Kattah AG, Smith CY, Rocca LG et al
CKD in Patients with Bilateral Oophorectomy.
CJASN September 2018, CJN.03990318
PMID: 30232136
https://cjasn.asnjournals.org/content/early/2018/09/19/CJN.03990318