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osteocalcin in serum
Indications:
-> monitoring calcitriol therapy
Specimen:
1) serum (fasting)
2) freeze immediately
3) stable for 14 months at -20 degrees C
Reference values:
1) 2.4-11.7 ng/mL (adults)
2) values are higher in children & post-menopausal women
Method: RIA
Increases:
1) clinical disorders
a) Paget's disease of the bone
b) renal osteodystrophy
c) hyperthyroidism (primary & secondary)
d) metastatic skeletal disease
e) chronic renal failure
f) osteoporosis (some patients)
g) adolescent growth spurt
2) pharmaceutical agents
- in vivo effects
- anticonvulsants, calcitriol, estrogens
Decreases:
1) clinical disorders
a) primary biliary cirrhosis
b) pregnancy
c) growth hormone deficiency
2) pharmaceutical agents
- in vivo effects
- glucocorticoids
Clinical significance:
- increased levels of osteocalcin in the serum reflect osteoblastic activity, NOT bone resorption
- serum osteocalcin is considered a sensitive marker of bone metabolism
- during osteoclastic activity, osteocalcin is released into the circulation as fragments cleared by the kidney, subsequently appearing in the urine as gamma-carboxyglutamate residue containing peptides
- serum osteocalcin levels generally parallel serum alkaline phosphatase levels
Related
osteoblast
osteocalcin; bone GLA protein; gamma-carboxyglutamic acid-containing protein (BGP, BGLAP)
Paget's disease of the bone; osteitis deformans
renal osteodystrophy
Specific
osteocalcin bovine in serum/plasma
General
special chemistry test
References
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- Osteocalcin by ECIA
Laboratory Test Directory ARUP: 20728
Component-of
bone/joint panel