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osteocalcin; bone GLA protein; gamma-carboxyglutamic acid-containing protein (BGP, BGLAP)
Function:
- vitamin K-dependent bone protein
- major non collagenous protein in bone
- constitutes 1-2% of the total bone protein
- the exact biological function of osteocalcin is not known, but the 3 gamma-carboxyglutamate residues confer on it strong binding of Ca+2 & hydroxyapatite
Structure:
- belongs to the osteocalcin/matrix Gla protein family
- contains 1 Gla domain (gamma-carboxyglutamate) domain
Compartment:
- secreted osteocalcin is mostly incorporated into bone matrix, with some escaping into the blood
Expression:
- synthesized exclusively by non proliferating osteoblasts in a mineralizing extracellular matrix
Pharmacology:
- warfarin, because it inhibits formation of gamma-carboxyglutamate residues inhibits maturaton of osteocalcin
Related
osteocalcin gene
osteocalcin in serum
General
secreted peptide
Properties
SIZE: entity length = 100 aa
MW = 11 kD
entity length = 24 aa
MW = 3 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
Gla {52-98}
MOTIF: proline residue {60}
Ca+2-binding site
SITE: 68-68
Ca+2-binding site
SITE: 72-72
cysteine residue {C74}
MODIFICATION: cysteine residue {C80}
Ca+2-binding site
SITE: 75-75
cysteine residue {C80}
MODIFICATION: cysteine residue {C74}
Ca+2-binding site
SITE: 81-81
SECRETED-BY: osteoblast
MISC-INFO: 1/2life 90 MIN
Database Correlations
OMIM 112260
SWISS-PROT correlations
Pfam PF00594
References
- Greendale, Multicampus Program in Geriatrics & Gerontology, 2001
- Dabbs. Diagnostic Immunohistochemistry. Churchill Livingstone 2002.
page 73
- UniProt :accession P84351
- UniProt :accession P02818
- Wikipedia; Note: osteocalcin entry
http://en.wikipedia.org/wiki/osteocalcin
- SeattleSNPs
http://pga.gs.washington.edu/data/bglap