Contents

Search

osteitis fibrosa cystica; von Recklinghausen's disease of bone

Etiology: - sustained hyperparathyroidism - most commonly seen in patients with chronic renal failure - rarely seen with severe primary hyperparathyroidism [1] Epidemiology: 1) now uncommon 2) in the past 25% of patients with hyperparathyroidism Pathology: 1) increased osteoclastic resorption of calcified bone with replacement by soft tissue - increased multinucleated osteoclasts 2) reduction in the number or trabecula 3) bone cysts Radiology: 1) punched-out lesions in the skull 2) subperiosteal absorption of bone in the digits * images [4] Differential diagnosis: - osteomalacia - adynamic bone disease

General

osteitis hyperparathyroidism

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 11, 18. American College of Physicians, Philadelphia 1998, 2018
  2. Stedman's Medical Dictionary 26th ed, Williams & Wilkins, Baltimore, 1995
  3. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 1253
  4. Ramon A, Berthod PE Images in Clinical Medicine. Osteitis Fibrosa Cystica. N Engl J Med 2020; 382:e15. March 12. PMID: 32160666 https://www.nejm.org/doi/full/10.1056/NEJMicm1907828?query=TOC