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erythrocyte osmotic fragility
Indications:
- evaluation of
- hereditary spherocytosis
- thalassemia
Reference values:
-> hemolysis occurs within range of 0.3-0.5% NaCl (normal saline is 0.9% NaCl)
Clinical significance:
- osmotic fragility is increased if hemolysis occurs in > 0.5% NaCl
- osmotic fragility is decreased if hemolysis is incomplete in 0.3% NaCl
Increases:
- causes of increased osmotic fragility
a) hereditary spherocytosis
b) thalassemia
General
clinical hematology test
References
- Medical Knowledge Self Assessment Program (MKSAP) 11,
American College of Physicians, Philadelphia 1998
- Medline Plus: Osmotic fragility
http://www.nlm.nih.gov/medlineplus/ency/article/003641.htm
- Osmotic Fragility
Laboratory Test Directory ARUP: 2002257