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glycerol; glycerin (Osmoglyn)
Pharmacology:
Indications:
- laxative
- constipation, bowel preparation,
- topical agent
- xerosis, skin irritation
- seborrheic dermatitis, dandruff
- psoriasis
- keratoderma
- acne [3]
- osmotic diuretic
- calcium stonte
- reduction of intraocular pressure
- glaucoma [3]
- ophthalmic
- dry eyes
- reduction of corneal edema
- Sjogren's syndrome [3]
- increased intracranial pressure
- cerebral edema [3]
Dosage:
1) laxative:
a) insert suppository high in rectum & retain for 15 minutes
b) repeat once/day as needed
2) osmotic diuretic
3) reduction of intraocular pressure
a) 1-1.8 g/kg PO 1-1.5 hour preoperatively
b) additional doses may be administered at 5 hour intervals
4) reduction of intracranial pressure
a) 1.5 g/kg/day PO divided every 4 hours
b) 1.0 g/kg PO every 6 hours has also been used
Solution: (oral) 50%, 180 mL.
Pharmacokinetics:
1) not absorbed when administered PR
2) onset of bowel relief is 15-30 minutes
Adverse effects:
1) common (> 10%)
- headache, nausea/vomiting
2) less common (1-10%)
- diarrhea, dry mouth, polydipsia, confusion, dizziness
3) uncommon (< 1%)
- arrhythmias, hyperglycemia, tenesmus, rectal irritation, cramping pain
Interactions
molecular events
drug interactions
drug adverse effects (more general classes)
Specific
glycerol-3-phosphate
General
cryoprotective agent
diuretic
laxative
sugar alcohol
Properties
MISC-INFO: elimination route FECES
pregnancy-category C
safety in lactation ?
Database Correlations
PUBCHEM cid=753
References
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Deprecated Reference
Component-of
8 hydroxyquinoline/acetic acid/glycerol
acetic acid/antipyrene/glycerol/8-OH quinoline
acetic acid/glycerol
alanine/arginine/calcium acetate/cysteine/glycerol/glycine/histidine/isoleucine/leucine/lysine/methionine/phenylalanine/phosphoric acid/potassium chloride/proline/serine/sodium acetate/sodium chloride/threonine/tryptophan/valine
alanine/arginine/calcium acetate/cysteine/glycerol/glycine/histidine/isoleucine/leucine/lysine/methionine/phenylalanine/potassium chloride/proline/serine/sodium acetate/sodium chloride/threonine/tryptophan/valine
allantoin/glycerol
artificial tears/glycerol/naphazoline
benzocaine/glycerol
carboxymethylcellulose/glycerol
carboxymethylcellulose/glycerol/polysorbate
dextran/glycerol
dextran/glycerol/hydroxypropyl methylcellulose
dimethicone/glycerol
docosanol/glycerol/lidocaine
dyclonine/glycerol
glycerol/hydroxypropyl methylcellulose
glycerol/hydroxypropyl methylcellulose/naphazoline
glycerol/hydroxypropyl methylcellulose/polyethylene glycol
glycerol/hydroxypropyl methylcellulose/polyethylene glycol/tetrahydrozoline
glycerol/hydroxypropyl methylcellulose/polyethylene glycol/tetrahydrozoline/zinc sulfate
glycerol/hydroxypropyl methylcellulose/propylene glycol
glycerol/isopropanol
glycerol/lidocaine
glycerol/lidocaine/mineral oil/petrolatum/phenylephrine
glycerol/lidocaine/petrolatum/phenylephrine
glycerol/lidocaine/phenylephrine
glycerol/naphazoline
glycerol/naphazoline/nov protein
glycerol/naphazoline/zinc sulfate
glycerol/naphazoline/zinc/zinc sulfate
glycerol/panthenol/vitamin e
glycerol/phenol
glycerol/phenylephrine
glycerol/phenylephrine/pramoxine/white petrolatum
glycerol/phospholipid
glycerol/polyethylene glycol
glycerol/polysorbate
glycerol/povidone
glycerol/pramoxine
glycerol/propylene glycol
glycerol/safflower oil/soy oil
glycerol/saline nasal spray/sodium chloride
glycerol/sodium chloride
glycerol/soy oil
glycerol/witch hazel
Unna's boot (Gelocast)