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Ortho-Novum 7/7/7, Tri-Norinyl, Estrostep

ethinyl estradiol (estrogen) plus norethindrone (progestin) Indications: 1) prevention of pregnancy 2) treatment of hypermenorrhea 3) endometriosis 4) female hypogonadism 5) acne is young women [3] Contraindications: pregnancy-category X safety in lactation - Pharmacokinetics: elimination: liver Adverse effects: 1) common (> 10%) - nausea, peripheral edema, breast enlargement, breast tenderness, anorexia, bloating 2) not common (1-10%) - vomiting, diarrhea, increased libido, headache 3) uncommon (< 1%) - intolerance to contact lenses, breast tumors, amenorrhea, alterations in mestrual flow, hypertension, thromboembolism, stroke, myocardial infarction, edema, depression, dizziness, anxiety, chloasma, melasma, rash, hyperglycemia, GI distress, increased serum triglycerides, increased LDL, cholestatic jaundice, increased susceptibility to Candida infection Drug interactions: - barbiturates, carbamazepine, cyclosporine, griseofulvin, penicillins, phenytoin, rifampin, tetracyclines

Interactions

drug adverse effects of estrogens

General

triphasic oral contraceptive ethinyl estradiol/norethindrone (Junel Fe)

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. Prescriber's Letter 8(8): 45, 2001
  4. Department of Veterans Affairs, VA National Formulary