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Ortho-Norvum 1/50, Genora 1/50, Nelova 1/50M, Norinyl 1+50
50 ug mestranol (estrogen) plus 1 mg norethindrone (progestin)
Indications:
1) prevention of pregnancy
2) treatment of hypermenorrhea
3) endometriosis
4) female hypogonadism
Contraindications:
pregnancy-category X
safety in lactation -
Pharmacokinetics: elimination: liver
Adverse effects:
1) common (> 10%)
- nausea, peripheral edema, enlargement of breasts, breast tenderness, anorexia, bloating
2) less common (1-10%)
- vomiting, diarrhea, increased libido, headache
3) uncommon (< 1%)
- intolerance to contact lenses, breast tumors, amenorrhea, alterations in frequency & flow of menses, hypertension, thromboembolism, stroke, myocardial infarction, edema, depression, dizziness, anxiety, chloasma, melasma, rash, impaired glucose tolerance, GI distress, increased triglycerides & LDL, cholestatic jaundice, increased susceptibility to Candida infection
Drug interactions:
1) barbiturates
2) carbamazepine (Tegretol)
3) cyclosporine
4) griseofulvin
5) penicillins
6) phenytoin (Dilantin)
7) rifampin
8) tetracyclines
Interactions
drug adverse effects of estrogens
General
monophasic oral contraceptive
mestranol/norethindrone
References
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998