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alpha-1 acid glycoprotein; orosomucoid
Product of a multigene family.
Pathology:
- elevated in chronic inflammatory & degenerative disease
- highly elevated in a number of different malignant diseases
Pharmacology:
- the major protein in plasma which binds basic drugs
Laboratory:
- serum protein electrophoresis
- orosomucoid or alpha-1 acid glycoprotein normally accounts for <30% of alpha-1 band
- generally responsible for elevation of the alpha-1 fraction
- labs with Loincs
- alpha-1 acid glycoprotein in body fluid
- alpha-1 acid glycoprotein in CSF
- alpha-1 acid glycoprotein in serum/plasma
- alpha-1 acid glycoprotein in urine
Specific
alpha-1-acid glycoprotein 1; AGP 1; orosomucoid-1; OMD 1 (ORM1, AGP1)
alpha-1-acid glycoprotein 2; AGP 2; orosomucoid-2; OMD 2 (ORM2, AGP2)
General
acute phase protein
alpha 1 globulin
lipocalin
mucoprotein
Properties
SIZE: MW = 40 kD
COMPARTMENT: plasma
MOTIF: glycosylation site (5)
binding site
EFFECTOR-BOUND: progesterone
MISC-INFO: lifetime 5 DAYS {1/2-LIFE}
pI 2.7
CONCENTRATION 40-105 MG/DL
References
- Tietz Fundamentals of Clinical Chemistry 3rd ed, WB
Saunders, 1987 pg 330
- OMIM :accession 176300
- Clinical Diagnosis & Management by Laboratory Methods,
J.B. Henry (ed), W.B. Saunders Co., Philadelphia,
PA. 1991, pg 224
- Clinical Chemistry, Principles, Procedures,
Correlations, 2nd ed., Bishop, Duben-Engelkirk, Fody
(eds), JB Lippincott, Philadelphia, 1991 pg 183