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ornithine decarboxylase 1
Function:
- amine & polyamine biosynthesis
- putrescine biosynthesis via L-ornithine pathway
- putrescine from L-ornithine: step 1/1
L-ornithine putrescine + CO2
Cofactor: pyridoxal phosphate
Structure:
- homodimer
- belongs to the orn/Lys/Arg decarboxylase class-II family
Expression:
- peaks in G1 prior to DNA synthesis & again in G2/M, eliciting comparable changes in polyamine synthesis
Pathology:
- may confer transforming properties to 3T3 cells
Interactions
molecular events
Related
antizyme inhibitor 1; AZI; ornithine decarboxylase antizyme inhibitor (AZIN1, OAZI, OAZIN)
arginine decarboxylase; ADC; ARGDC; ODC-paralogue; ODC-p; ornithine decarboxylase-like protein (ADC KIAA1945 ODCP)
ornithine decarboxylase antizyme
General
carboxy-lyase or decarboxylase
PEST protein
Properties
SIZE: entity length = 461 aa
MW = 51 kD
MOTIF: cofactor-binding site [69-69]
FOR-BINDING-OF: pyridoxal phosphate
Ser phosphorylation site {S303}
cysteine residue {C360}
MISC-INFO: 1/2life 0.5 HOURS
Database Correlations
OMIM 165640
UniProt P11926
PFAM correlations
LOCUS-LINK correlations
KEGG correlations
ENZYME 4.1.1.17
References
- Auvinen eta al Nature 360:355 1992
- Rogers S et al,
Amino acids common to rapidly degraded proteins: The PEST
hypothesis
Science 234:364 1986 (1/2life)
PMID: 2876518
- Wikipedia, ornithine decarboxylase entry
http://en.wikipedia.org/wiki/ornithine_decarboxylase
- UniProt :accession P11926