origin of replication complex (origin recognition complex, ORC)

Function: - binds to origin of DNA replication & with help from two further protein factors (Cdc6 & Cdt1), load the minichromosome maintenance protein complex to form the pre-replication complex - once assembled, the pre-replication complex unwinds, & begins to copy DNA Structure: 1) heterohexamer 2) subunits origin recognition complex subunit 1 origin recognition complex subunit 2 origin recognition complex subunit 3 origin recognition complex subunit 4 origin recognition complex subunit 5 origin recognition complex subunit 6

General

DNA-binding protein molecular complex

Properties

COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SUBUNITS: ORIGIN-OF-REPLICATION-COMPLEX-SUBUNIT-1 ORIGIN-OF-REPLICATION-COMPLEX-SUBUNIT-2 ORIGIN-OF-REPLICATION-COMPLEX-SUBUNIT-3 ORIGIN-OF-REPLICATION-COMPLEX-SUBUNIT-4 ORIGIN-OF-REPLICATION-COMPLEX-SUBUNIT-5 ORIGIN-OF-REPLICATION-COMPLEX-SUBUNIT-6