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oral insulin
Indications:
- investigational treatment of diabetes mellitus
Mechanism of action:
- tiny (5-mm diameter) devices with flat bottoms
- when swallowed, device rolls on the mucosal surface of the stomach until the flat bottom contacts the gastric mucosa
- the device then stays in that position, & gastric fluid triggers a tiny spring that pushes a small needle, covered with therapeutic biomacromolecules, into the gastric mucosa
- the macromolecules are absorbed into the bloodstream, & the device passes out of the body in the feces
Interactions
drug adverse effects of hypoglycemic agents
General
pharmaceutical insulin
oral hypoglycemic agent
References
- Abramson A, Caffarel-Salvador E, Khang M et al.
An ingestible self-orienting system for oral delivery of macromolecules.
Science 2019 Feb 8; 363:611
PMID: 30733413
http://science.sciencemag.org/content/363/6427/611