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endorphin receptor or opioid receptor
Function:
- endorphin or opioid receptors are coupled to Gi
- the opioid receptors also mediate effects on Ca+2 channel & K+ channel activity
Expression:
- areas of the brain rich in opioid receptors include:
a) rostral anterior cingulate cortex
b) lower brainstem
Related
brainstem
cingulate gyrus; gyrus cinguli; cingulate cortex
endorphin
Specific
delta opioid receptor; DOR-1 (OPRD1, OPRD)
kappa opioid receptor; KOR-1 (OPRK1 OPRK)
mu opioid receptor; MOR-1 (OPRM1, MOR1)
nociceptin receptor; orphanin FQ receptor; kappa-type 3 opioid receptor; KOR-3 (OPRL1 OOR ORL1)
opioid growth factor receptor (opioid growth factor receptor, OGFr, 7-60 protein)
opioid sigma receptor
probable opioid receptor ORL1
General
G-protein coupled receptor; serpentine receptor
synaptic receptor
Properties
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {N-TERMINAL}
ligand-binding site
SITE: WITHIN-MEMBRANE-DOMAINS
FOR-BINDING-OF: norepinephrine
epinephrine
transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
transmembrane domain {TM4}
transmembrane domain {TM5}
binding site
SITE: L5
FOR-BINDING-OF: Gi-protein
transmembrane domain {TM6}
transmembrane domain (7)
binding site
SITE: C-TERMINAL-CYS
EFFECTOR-BOUND: palmitate
BOUND-VIA: carboxylate
transmembrane domain {TM7}
cytoplasmic domain {C-TERMINAL}
References
- Reisine T, Bell GI.
Molecular biology of opioid receptors.
Trends Neurosci. 1993 Dec;16(12):506-10. Review.
PMID: 7509520
- Journal Watch 22(7):56, 2002